Natraj Krishnan

Natraj Krishnan

Associate Professor
Graduate Coordinator

Insect Physiology

Research Areas:
  • Insect-Plant Interactions
  • Oxidative stress and regulation of antioxidant response in insect digestion
  • Neuro-endocrine and circadian control of response to oxidative stress in insect systems
  • Mode of action of insect growth regulators
  • Modeling neurodegenerative diseases in Drosophila melanogaster
  • Circadian regulation of cellular homeostasis
  • Exploring the role of matrix metalloproteinases in neuronal remodeling and regeneration
  • tRNA modifications and their relationship to neurophysiology
  • SUMOylation and its role in neuronal health

Courses Taught:
  • BCH 1011 - First Year Seminar - Natures Timepiece (offered in Fall)
  • BCH 4113/6113 - Essentials of Molecular Genetics (offered Summer 10 week, online)
  • BCH 4414/6414 - Protein Methods (offered in Fall)
  • BCH 4623/6623 - Biochem Spec Tissues/Medical Biochem (offered in Spring)
  • EPP 4333/6333 - Principles of Insect Anatomy and Physiology (offered in Spring online)
  • EPP 8343 - Advances in Insect Anatomy - Structure and Function (offered in Fall, even years)
  • EPP 8353 - Advances in Insect Physiology and Biochemistry (offered in Fall, odd years)

Society Membership:
  • Entomological Society of America
  • Society for Integrative and Comparative Biology


  • Dvořáček J., A. Bednářová., N. Krishnan., D. Kodrík. 2022. Dopaminergic mushroom body neurons in Drosophila: Flexibility of neuron identity in a model organism? Neuroscience and Biobehavioral Review 135:104570.  Download
  • Catchot, B. D., F. R. Musser, J. Gore, N. Krishnan, D. R. Cook, S. D. Stewart, G. M. Lorenz, S. Brown, N. Seiter, A. L. Catchot, D. L. Kerns, R. Jackson, K. S. Knighten. 2021. Sublethal impacts of novaluron on tarnished plant bug (Hemiptera: Miridae) adults. Journal of Economic Entomology 114(2):739-746. Download
  • Hearst, S, A. Bednářová., B. Draughn., K. Johnson, D. Mills, C. Thomas, J. Scales., E. T. Keenan., J. V. Welcher, N. Krishnan. 2021. Expression of Drosophila matrix metalloproteinases in cultured cell lines alters neural and glial cell morphology. Frontiers in Cell and Developmental Biology 9:1242.  Download
  • Whalen, A., A. L. Catchot Jr., J. Gore, S. D. Stewart, G. M. Lorenz, D. R. Cook, F. R. Musser, J. W. Harris, N. Krishnan. 2021. Temporal Profile of Neonicotinoid Concentrations in Cotton, Corn, and Soybean Resulting from Insecticidal Seed Treatments. Agronomy 11(6):1200. Download
  • Bednářová, A., M. Kropf, N. Krishnan. 2020. The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study. Ecotoxicology and Environmental Safety 188:109883.  Download
  • Catchot, B., C. J. Anderson, J. Gore, R. Jackson, K. Rakshit, F. Musser, N. Krishnan. 2020. Novaluron prevents oogenesis and oviposition by inducing ultrastructural changes in ovarian tissue of young adult Lygus lineolaris. Pest Management Science.  Download
  • Chaudhuri, A., R. Johnson, K. Rakshit, A. Bednářová, K. Lackey, S.S. Chakraborty, N. Krishnan, A.Chaudhuri. 2020. Exposure to Spectracide® causes behavioral deficits in Drosophila melanogaster: Insights from locomotor analysis and molecular modeling. Chemosphere. 248:126037.  Download
  • Yue, Z., N. Krishnan, T. M. Tseng. 2020. Antifeedant effect of sicklepod extract on soybean looper Chrysodeixis includens (Lepidoptera: Noctuidae). Mississippi Academy of Sciences Journal 65(3): 293-300.
  • Bednářová, A., A. Tomčala, M. Mochanová, D. Kodrik, N. Krishnan. 2018. Disruption of adipokinetic hormone medicated energy homeostasis has subtle effects on physiology, behavior and lipid status during aging in drosophila. Frontiers in Physiology 9:949 Download
  • Bednářová, A., D. Kodrik, A. Chaudhuri, N. Krishnan. 2018. Neuroendocrine regulation of homeostasis in insects: Implications for metabolic disorders in humans. Advances in Health and Disease 3:1-45.
  • Formby, J. P., J. C. Rodgers, F. H. Koch, N. Krishnan, D. A. Duerr, J. J. Riggins. 2018. Cold tolerance strategy and invasive potential of the redbay ambrosia beetle (Xyleborus glabratus) in the eastern United States. Biological Invasions 20:995-1007. Download
  • Bednářová, A., M. E. Hanna, K. Rakshit, J. M. O'Donnell, N. Krishnan. 2017. Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster. The European Journal of Neuroscience 45(6):816-825. Download
  • Bednářová, A., M. Hanna, I. Durham, T. VanCleave, A. England, A. Chaudhuri, N. Krishnan. 2017. Lost in translation: Defects in transfer RNA modifications and neurological disorders. Frontiers in Molecular Neuroscience 10:135. Download
  • Fleming, D. E., N. Krishnan, F. Musser 2017. Polygalacturonase gene expression and enzymatic activity in salivary glands of laboratory reared and wild populations of Lygus lineolaris (Hemiptera: Miridae). European Journal of Entomology 114:16-24. Download
  • Adams, A., J. Gore, A. L. Catchot, F. Musser, D. R. Cook, N. Krishnan, J. T. Irby. 2016. Residual and systemic efficacy of chlorantraniliprole and flubendiamide against corn earworm (Lepidoptera: Noctuidae) in soybean. Journal of Economic Entomology 109(6):2411-2417. Download
  • Adams, A., J. Gore, A. L. Catchot, F. Musser, D. R. Cook, N. Krishnan, J. T. Irby. 2016. Susceptibility of Helicoverpa zea (Lepidoptera: Noctuidae) neonates to diamide insecticides in the Midsouthern and Southeastern United States. Journal of Economic Entomology 109(3):1161-1166. Download
  • Fleming, D. E., N. Krishnan, A. L. Catchot, F. R. Musser. 2016. Susceptibility to insecticides and activities of glutathion S-transferase and esterase in populations of Lygus lineolaris (Hemiptera:Miridae) in Mississippi. Pest Management Science 72(8):1595-1603. Download
  • Giejdasz, K., M. Fliszkiewicz, A. Bednarova, N. Krishnan. 2016. Reproductive potential and nesting effects of Osmia rufa (syn. bicornis) female (Hymenoptera: Megachilidae). Journal of Apicultural Science 60(1). Download
  • Krishnan, N., K. Giejdasz, M. Fliszkiewicz, A. Bednarova. 2016. Reproductive potential and nesting effects of Osmia rufa (syn. bicornis) female (Hymenoptera: Megachilidae). Journal of Apicultural Science 60(1):75-86. Download
  • Bednářová, A., D. Kodrik, N. Krishnan. 2015. Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila—a role for dFoxO? Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology 171:8-14. Download
  • Hanna, M., E., A. Bednarova, K. Rakshit, A. Chaudhuri, J. M. O'Donnell, N. Krishnan. 2015. Perturbations in dopamine synthesis lead to discrete physiological effects and impact oxidative stress response in Drosophila. Journal of Insect Physiology 73:11-19. Download
  • Kodrik, D., A. Bednarova, M. Zemanova, N. Krishnan. 2015. Hormonal regulation of response to oxidative stress in insects-an update. International Journal of Molecular Sciences 16(10):25788-25816. Download
  • Wasielewski, O., T. Wojciechowicz, K. Giejdasz, N. Krishnan. 2015. Enhanced UV-B radiation during pupal stage reduce body mass and fat content, while increasing deformities, mortality and cell death in female adults of solitary bee Osmia bicornis. Insect Science 22(4):512-520. Download
  • Bednářová, A., D. Kodrik, N. Krishnan. 2013. Adipokinetic hormone exerts its antioxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores. Comparative Biochemistry and Physiology, 158(3):142-149. Download
  • Bednářová, A., D. Kodrik, N. Krishnan. 2013. Unique roles of glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects. Comparative Biochemistry and Physiology, 164(1):91-100. Download
  • Bednářová, A., N. Krishnan, I.C. Cheng, J. Vecera, H.J. Lee, D. Kodrik. 2013. Adipokinetic hormone counteracts oxidative stress elicited in insects by hydrogen peroxide: in vivo and in vitro study. Physiological Entomology, 38:54-62. Download
  • Ivanchenko, M.G., D. den Os, G.B. Monhausen, A. Bednarova, N. Krishnan. 2013. Auxin increases the hydrogen peroxide (h2o2) concentration in tomato (Solanum lycopersicum) root tips while inhibiting root growth. Annals of Botany, 112(6):1107-1116. Download
  • Vinokurov, K., A. Bednarova, A. Tomcala, T. Staskova, N. Krishnan, D. Kodrik. 2013. Role of adipokinetic hormone in stimulation of salivary gland activities: the fire bug Pyrrhocoris apterus L. (Heteroptera) as a model species. Journal of Insect Physiology. Download
  • Wasielewski, O., T. Wojciechowicz, K. Giejdasz, N. Krishnan. 2013. Overwintering strategies in the red mason solitary bee - physiological correlates of midgut metabolic activity and turnover of nutrient reserves in females of Osmia bicornis. Apidologie. Download
  • Fliszkiewicz, M., K. Giejdasz, O. Wasielewski, N. Krishnan. 2012. Influence of winter temperature and simulated climate change on body mass and fat body depletion during diapause in adults of the solitary bee, Osmia rufa (Hymenoptera: Megachilidae). Environmental Entomology 41(6):1621-1630. Download
  • Krishnan, N., D. Kodrik. 2012. Endocrine control of oxidative stress in insects. Pages 261-270 in Farooqui and Farooqui, editors, Molecular Aspects of Oxidative Stress in Cell Signaling in Vertebrates and Invertebrates. Wiley-Blackwell Publishers. Download
  • Krishnan, N., K. Rakshit, E.S. Chow, J.S. Wentzell, D. Kretzshmar, J.M. Giebultowicz. 2012. Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Neurobiology of Disease 45(3):1129-1135. Download
  • Meermeier, N.,N. Krishnan. 2012. Circadian regulation of cellular homeostasis-implications for cell metabolism and clinical diseases. Medical Hypotheses 79(1):17-24. Download
  • Rakshit, K., N. Krishnan, E.M. Guzik, E. Pyza, J.M. Giebultowicz. 2012. Effects of aging on the molecular circadian oscillations in Drosophila. Chronobiology International 29(1):5-14. Download
  • Rakshit, K., N. Krishnan. 2012. Orchestration of oxidative stress responses in Drosophila melanogaster: A promoter analysis study of circadian regulatory motifs. Pages 327-335 in Faroqui and Farooqui, editors, Molecular Aspects of Oxidative Stress in Cell Signaling in Vertebrates and Invertebrates. Wiley-Blackwell Publishers.
  • Veoera, J., N. Krishnan, A. Mithofer, H. Vogel, D. Kodrik. 2012. Adipokinetic hormone-induced antioxidant response in Spodoptera littoralis. Comparative Biochemistry and Physiology 155(2):389-395. Download
  • Wasielewski, O., T. Wojciechowicz, K. Giejdasz, and N. Krishnan. 2011. Influence of methoprene and temperature on diapause termination in adult females of the over-wintering solitary bee, Osmia rufa L. Journal of Insect Physiology 57(12):1682-1688. Download